
Mini-Brains Reveal a Hidden Driver of Tau Pathology in Dementia
In a significant step forward for neurodegeneration research, scientists have uncovered a key player in the cellular chaos that underlies diseases like Alzheimer’s and frontotemporal dementia: a cholesterol transporter called GRAMD1B. The findings, published in Nature Communications by a multi-institutional team led by researchers at The Ohio State University, point to GRAMD1B as a central…
Mitochondrial Transplantation Shows Promise for Neurodegeneration in Mice
A new Nature Communications study has explored the potential of mitochondrial transplantation as a therapeutic approach for cerebellar neurodegeneration. Led by researchers at the Air Force Medical University (Fourth Military Medical University), Xi’an, China, the study demonstrates how liver-derived mitochondria injected into the cerebellum of genetically modified mice can restore mitochondrial function, reduce mitophagy, and…
Zinc Finger Repressors Show Promise in Treating Prion Disease
A recent preprint published on bioRxiv introduces a novel approach to treating prion diseases, a group of fatal neurodegenerative disorders, using Zinc Finger Repressors (ZFRs). Researchers from Sangamo Therapeutics, the Broad Institute of MIT and Harvard, and Evotec SE have demonstrated that these engineered proteins can significantly reduce prion protein (PrP) levels in the brain—an…
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