Research brief
The hippocampus, vital for memory and cognition, changes structurally throughout life. Researchers have mapped these changes using data from over 27,000 individuals across 158 scanning sites. The study shows how aspects of hippocampal geometry, like lamellar thickness, width, and length, vary with age. It also identifies distinct patterns linked to various brain disorders, providing a clearer picture of hippocampal morphology in both health and disease.
Key points
- Hippocampal geometry changes non-uniformly with age.
- Study analysed data from over 27,000 individuals.
- Findings reveal distinct disease-associated patterns.
Understanding Hippocampal Geometry
This study creates normative models of hippocampal geometry, focusing on lamellar morphology. By examining a large cohort, researchers have mapped how the hippocampus changes over a lifetime. The results show that lamellar thickness, width, and length each follow their own developmental and aging paths, challenging earlier views that treated the hippocampus as a uniform structure.
Disease-Associated Patterns
The research identifies differences in how various brain disorders impact hippocampal structure. Neurodegenerative diseases and schizophrenia are linked to widespread atrophy, while other conditions may cause focal or regionally selective hypertrophy. These insights extend beyond traditional subfield-level analyses, offering a more detailed view of disease manifestations in the hippocampus.
Clinical Implications
The study’s findings have practical applications, particularly in Alzheimer’s research. By applying this model to a longitudinal cohort from the Alzheimer’s Disease Neuroimaging Initiative, researchers demonstrated its ability to generalise beyond the initial sample. This enables tracking and risk assessment at the individual level, potentially aiding in early diagnosis and intervention strategies for Alzheimer’s and other neurodegenerative diseases.
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